De Marzo Laboratory

in the Johns Hopkins Department of Pathology

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c-MYC in Prostate Cancer

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis - 2008 PDF File TMAJ icon
MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells -- 2010 PDF File TMAJ icon
MYC and Prostate Cancer -- 2010 PDF File
Am. J. Pathol - Alterations in Nucleolar Structure and Gene Expression Programs in Prostatic Neoplasia Are Driven by the MYC Oncogene. - 2011 TMAJ icon

Prostate Inflammation and Atrophy in Prostate Carcinogenesis

Am. J. Pathol - First Paper Proposing PIA as a Term and as Potential Precursor to PIN and Cancer - 1999 TMAJ icon
Urology - Paper Documenting Merging of PIA and PIN - 2000 PDF File
Cancer Research - COX-2 Overexpression in PIA - 2001 PDF File TMAJ icon
Urology - GSTA1 Overexpression in PIA - 2001 PDF File
Am. J. Pathol - PIA is Enriched in Intermediate Cells - 2003 TMAJ icon
Am. J. Pathol - GSTP1 Methylation in PIA, PIN and Cancer by Laser Capture Microdissection - 2003 TMAJ icon
Decreased NKX3.1 Protein Expression in Focal Prostatic Atrophy, Prostatic Intraepithelial Neoplasia, and Adenocarcinoma: Association with Gleason Score and Chromosome 8p Deletion - 2006 PDF File TMAJ icon
A Working Group Classification of Focal Prostate Atrophy Lesions - 2006 PDF File TMAJ icon

Telomere Length Analysis and Genetic Instability in Cancer

Am. J. Pathol - Tel-I-FISH Method Paper - 2002 TMAJ icon
Cancer Research - Telomeres Shortening in High Grade PIN - 2002 PDF File

Review Articles

Urology - New Concepts Review - 1999 PDF File
Lancet - Review of Prostate Pathology and Disease Mechanisms - 2003 PDF File
New England Journal of Medicine - Mechanisms of Disease - 2003 PDF File
Urology - Human Prostate Cancer Precursors and Pathobiology, Supplement - 2003 PDF File
Journal of Cell Biochem - Pathological and Molecular Mechanisms of Prostate Carcinogenisis - 2004 PDF File
Cancer Letters - Cox-2 in Cancer - 2004 PDF File
Nature Reviews Cancer - Inflammation in Prostate Carcinogenesis - 2007 PDF File
Advances in Anatomic Pathology - Molecular Alterations in Prostate Cancer as Diagnostic, Prognostic, and Therapeutic Targets - 2008 PDF File
Tissue Microarrays in Cancer Research -- 2010 TMAJ icon

Other Primary Publications

Human Path - Inadequate Formalin Fixation and p27Kip1 in Prostate - 2001 PDF File
Cancer Research - Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer - 2002 PDF File TMAJ icon
The Prostate - Trefoil Factor 3 Overexpression in Prostate Cancer - 2004 PDF File TMAJ icon
A Novel Role of Myosin VI in Human Prostate Cancer - 2006 TMAJ icon
Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues - 2008 PDF File TMAJ icon
DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity -- 2008 PDF File
Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer -- 2009 PDF File
Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells -- 2009 PDF File
Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate -- 2009 PDF File
Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation -- 2011 PDF File TMAJ icon
Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines -- 2011 PDF File TMAJ icon
Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms -- 2011 PDF File TMAJ icon
PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients -- 2011 PDF File TMAJ icon


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